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KMID : 0624620170500040194
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BMB Reports
2017 Volume.50 No. 4 p.194 ~ p.200
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Translational control of mRNAs by 3′-Untranslated region binding proteins
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Yamashita Akio
Takeuchi Osamu
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Abstract
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Eukaryotic gene expression is precisely regulated at all points between transcription and translation. In this review, we focus on translational control mediated by the 3′-untranslated regions (UTRs) of mRNAs. mRNA 3′-UTRs contain cis-acting elements that function in the regulation of protein translation or mRNA decay. Each RNA binding protein that binds to these cis-acting elements regulates mRNA translation via various mechanisms targeting the mRNA cap structure, the eukaryotic initiation factor 4E (eIF4E)-eIF4G complex, ribosomes, and the poly (A) tail. We also discuss translation-mediated regulation of mRNA fate.
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KEYWORD
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RNA binding protein, Translation, Translation initiation, 3′-UTR
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